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February 1989

Kawasaki Disease With Thrombocytosis Followed by Thrombocytopenia Purpura in the Same Patient

Author Affiliations

Departments of Pediatrics and Laboratory Medicine Children's Hospital National Medical Center George Washington University Medical School 111 Michigan Ave NW Washington, DC 20010

Am J Dis Child. 1989;143(2):139-140. doi:10.1001/archpedi.1989.02150140021008

Sir.—Kawasaki disease has been commonly associated with numerous hematologic abnormalities, including anemia, leukocytosis, thrombocytosis, and enhanced platelet aggregation.1 However, thrombocytopenia has, to our knowledge, not been previously described. We describe a patient with Kawasaki disease who developed idiopathic thrombocytopenia purpura (ITP).

Patient Report.—A 9-year-old boy was in excellent health until he presented with an erythematous rash and spiking fever of six days' duration, arthralgias involving his hips and ankles, headache, and sore throat. The patient denied any history of cough, rhinorrhea, shortness of breath, nausea, vomiting, or other complaints. He had moved to the area from Colorado two weeks prior to admission and denied contact with any animals, chemicals, or other substances. The patient's medical history was unremarkable and he reported no allergies. The patient was admitted to the hospital and treated with cefuroxime for two days, but continued with high intermittent fever and was transferred to

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