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March 1989

Bone Mineral Status in Hypopituitarism

Author Affiliations

Department of Pediatrics Juntendo University School of Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113, Japan

Am J Dis Child. 1989;143(3):272-273. doi:10.1001/archpedi.1989.02150150022007

Sir.—we read with interest the article by Witz et al1 in the August 1988 issue of AJDC regarding growth disturbance in hypopituitarism and would like to add our observations on bone mineral status in patients with hypopituitarism.

The bone mineral status of nine male patients with hypopituitarism (due to various causes) was analyzed by single-photon absorptiometry at the nondominant distal radius. The patients were 14 to 21 years old (mean age, 18 years); the pubertal stage was Tanner I to II. Hand radiography showed that the epiphyses were open, and serum testosterone levels were below 4 nmol/L in the presence of low serum gonadotropin levels. All patients had received levothyroxine sodium and synthesized human growth hormone, three had received hydrocortisone (5 to 15 mg/d), and none had received sex steroid hormone replacement therapy.

In five of the nine patients, the radial bone mineral content (in grams per square

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