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June 1989

Growth Response of Growth Hormone-Deficient Patients to 0.06 mg/kg Compared With 0.10 mg/kg Three Times per Week of Biosynthetic Growth Hormone

Author Affiliations

Department of Pediatrics University of Florida College of Medicine PO Box J-296 J. Hillis Miller Health Center Gainesville, FL 32610

Am J Dis Child. 1989;143(6):642-643. doi:10.1001/archpedi.1989.02150180020008

Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.1 Raben2 established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier3 in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage.

The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer

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