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June 1989

Vitamin K Absorption Capacity and Its Association With Vitamin K Deficiency

Author Affiliations

From the Department of Pediatrics (Drs Shinzawa, Tsunei, and Shiraki) and the Division of Chemistry (Dr Mura), Institute of Steroid Research, Tottori University School of Medicine, Yonago, Japan.

Am J Dis Child. 1989;143(6):686-689. doi:10.1001/archpedi.1989.02150180064022

• We measured plasma vitamin K concentrations in 194 5-day-old infants three hours after administration of a 4-mg dose of vitamin K (menaquinone-4, Kaytwo syrup, Eisai Co Ltd, Tokyo, Japan). We investigated association with other factors contributing to vitamin K deficiency. These plasma vitamin K concentrations varied greatly among the neonates from values below the limit of detection (2 ng/mL) to more than 1000 ng/mL. The vitamin K concentration was associated with nutritive vitamin K deficiency represented by plasma protein induced by vitamin K absence or antagonist-II (PIVKA-II) values. The wide variation in vitamin K absorption is considered to be one of the major causative factors in infantile vitamin K deficiency.

(AJDC 1989;143:686-689)

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