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September 1989

Twice-Daily Therapy for Strep?-Reply

Author Affiliations

Associate Professor of Pediatrics Division of Infectious Diseases University of Connecticut Health Center Farmington, CT 06032

Am J Dis Child. 1989;143(9):997. doi:10.1001/archpedi.1989.02150210013003

In Reply.—In the conclusion of our article,1 we attempted to make a distinction between our recommendations and those of the AHA. As Dr Gill has correctly observed, the AHA does not list twice-daily penicillin therapy as an acceptable regimen for the treatment of streptococcal pharyngitis.2 However, based on our findings3 and those of several other investigators,4-8 we believe that twice-daily penicillin V therapy is an effective regimen. The Committee on Infectious Diseases of the American Academy of Pediatrics also notes that "with good compliance, two doses of oral pencillin totaling 800,000 U (500 mg) daily have been reported to be effective."9

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