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September 1989

Anti-Staphylococcus aureus IgE Antibodies for Diagnosis of Hyperimmunoglobulinemia E-Recurrent Infection Syndrome in Infancy

Author Affiliations

From the Department of Pediatrics, Division of Allergy-Immunology-Bone Marrow Transplantation, Children's Hospital of Philadelphia, University of Pennsylvania Medical School. Dr Lavoie is now with Unité de recherche, Inflammation et Immunologie-Rhumatologie, Centre Hospitalier de l'Université Laval. Dr Grodofsky is nowwith Pediatric Allergy Associates, Hartford, Conn.

Am J Dis Child. 1989;143(9):1038-1041. doi:10.1001/archpedi.1989.02150210064021

• Four infants with hyperimmunoglobulinemia E presented with a persistent papulovesicular rash and eosinophilia. Serum IgE levels and specific anti-Staphylococcus aureus IgE antibodies were studied during the first year of life. Increased anti-S aureus IgE antibodies were an early indicator of the disease; they appeared as soon as 7 weeks of age in patient 1 and before 1 year of age for the other patients. These antibodies were detected before the development of deeper staphylococcal infections. Prompt diagnosis and treatment are important, as they may prevent long-term infectious complications.

(AJDC. 1989;143:1038-1041)

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