• Four infants with hyperimmunoglobulinemia E presented with a persistent papulovesicular rash and eosinophilia. Serum IgE levels and specific anti-Staphylococcus aureus IgE antibodies were studied during the first year of life. Increased anti-S aureus IgE antibodies were an early indicator of the disease; they appeared as soon as 7 weeks of age in patient 1 and before 1 year of age for the other patients. These antibodies were detected before the development of deeper staphylococcal infections. Prompt diagnosis and treatment are important, as they may prevent long-term infectious complications.
Lavoie A, Rottem M, Grodofsky MP, Douglas SD. Anti-Staphylococcus aureus IgE Antibodies for Diagnosis of Hyperimmunoglobulinemia E-Recurrent Infection Syndrome in Infancy. Am J Dis Child. 1989;143(9):1038–1041. doi:10.1001/archpedi.1989.02150210064021
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.