Sir.—Since my original experience1 with cat-scratch disease, I have remained interested in it and impressed with its stubborn resistance to therapy.
During the last 3 months I have treated 11 children (Table) for catscratch disease with 20 mg/kg of trimethoprim-sulfamethoxazole twice daily for 7 days, and all 11 have shown prompt improvement. The enlarged nodes were visible, very tender, and firm without palpable suppuration. All of these patients were treated with trimethoprim-sulfamethoxazole twice daily within 7 days of the onset of their enlarged gland. The lymph nodes became nontender in 4 to 6 days, and smaller by 7 to 10 days. They were 10 mm or smaller by 3 weeks in all cases. Nine of 11 patients had a history of exposure to cats. There was a primary inoculation lesion (usually a scratch) in 7 of these 11 patients. My prior experience had been to treat them with