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November 1989

Cat-scratch Disease Therapy

Author Affiliations

176 Memorial Dr Jessup, GA 31545

Am J Dis Child. 1989;143(11):1261. doi:10.1001/archpedi.1989.02150230019008

Sir.—Since my original experience1 with cat-scratch disease, I have remained interested in it and impressed with its stubborn resistance to therapy.

During the last 3 months I have treated 11 children (Table) for catscratch disease with 20 mg/kg of trimethoprim-sulfamethoxazole twice daily for 7 days, and all 11 have shown prompt improvement. The enlarged nodes were visible, very tender, and firm without palpable suppuration. All of these patients were treated with trimethoprim-sulfamethoxazole twice daily within 7 days of the onset of their enlarged gland. The lymph nodes became nontender in 4 to 6 days, and smaller by 7 to 10 days. They were 10 mm or smaller by 3 weeks in all cases. Nine of 11 patients had a history of exposure to cats. There was a primary inoculation lesion (usually a scratch) in 7 of these 11 patients. My prior experience had been to treat them with

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