• In 22 patients with suspected diffuse goiter, the diagnostic accuracy of ultrasonography was compared with that of aspiration biopsy cytology and thyroid antibody testing. Ultrasonography was abnormal in 100% (10/10) of the patients with autoimmune thyroid disease, only 90% (9/10) of whom were identified with antibody testing. All patients with diffuse colloid goiter had normal echo patterns on ultrasound imaging, whereas 29% (2/7) of them had positive results on antibody testing. Whether these are 'false positives' or represent focal thyroiditis remains unclear. Thus, ultrasound imaging stands out as a valuable diagnostic tool for the differential diagnosis of diffuse thyroid disorders in children.
Ivarsson SA, Ericsson U, Fredriksson B, Persson PH. Ultrasonic Imaging in the Differential Diagnosis of Diffuse Thyroid Disorders in Children. Am J Dis Child. 1989;143(11):1369–1372. doi:10.1001/archpedi.1989.02150230127041
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