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December 1989

Perinatal Abnormalities and Subhypothalamic Bright Spot on Magnetic Resonance Imaging in Pituitary Dwarfs

Author Affiliations

Department of Pediatrics
Department of Radiology Kyushu University Faculty of Medicine 3-1-1 Maidashi, Higashi-ku Fukuoka 812, Japan
Department of Endocrinology and Metabolism Medical Center for Sick Children Fukuoka 810, Japan

Am J Dis Child. 1989;143(12):1394. doi:10.1001/archpedi.1989.02150240016008

Sir.—The survey results on magnetic resonance imaging (MRI) in patients with idiopathic pituitary dwarfism as reported by Root et al1 were interesting and warrant further observations. The authors demonstrated that MRI in two patients with pituitary dwarfism without asphyxia at birth (one had panhypopituitarism with intact posterior function, and the other had central hypothyroidism) had a signal of high intensity near the optic tract.2,3 A small pituitary gland and an unclear defined pituitary stalk were also observed.4

To ascertain that the hypopituitary state was a result of an insult to the pituitary stalk, we compared the T1-weighted MRI findings of the hypothalamic-pituitary structure in two groups, a total of 14 patients, of idiopathic pituitary dwarfs. The two groups were the following: those with perinatal abnormalities were group 1 (5 boys and 2 girls) (6 had had asphyxia at birth and 1, dystocia with vacuum

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