Down Syndrome and 3,3′,5′-Triiodothyronine

JÉRÔME LEJEUNE; MARIE PEETERS; MARIE ODILE RETHORE; MARIE CHRISTINE DE BLOIS; JEAN PIERRE DEVAUX

doi:10.1001/archpedi.1990.02150250021017

Article

January 1990

Down Syndrome and 3,3′,5′-Triiodothyronine

JÉRÔME LEJEUNE, MD, PHD; MARIE PEETERS, MD; MARIE ODILE RETHORE, MD; et al MARIE CHRISTINE DE BLOIS, MD; JEAN PIERRE DEVAUX, MD

Author Affiliations

Centre de Recherches Génétique Humaine et Maladies de l'Intelligence Institut de Progenèse 45, rue des Saints-Pères 75270 Paris cedex 06 France

Service Central des radio-isotopes Hôpital des Enfants Malades 149, rue de Sèvres 75743 Paris cedex 15 France

Am J Dis Child. 1990;144(1):19. doi:10.1001/archpedi.1990.02150250021017

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Abstract

Sir.—Since publications cross geographic but only rarely linguistic boundaries, we wish to bring to your attention our recent publication on elevated thyrotropin (TSH) levels and Down syndrome (DS).¹

Our findings are in accordance with those observed by Sharav et al.²

A prospective survey was carried out on 78 patients with DS (age range, 6 months to 16 years; mean, 9.08±6.99 years) followed up at our genetics clinic, Hopital des Enfants Malades, Paris, France. The TSH levels were significantly elevated (t = 9.5; P<<<.001) in the group with trisomy 21 (3.99±2.54 mU/L) as compared with 214 age-matched normal children (2.01±0.85 mU/L). There was no difference in free thyroxine (T₄) levels between both groups (trisomy 21, 20.55±3.81 pmol/L; controls, 21.12±3.19 pmol/L). Free triiodothyronine (T₃) levels, however, tended to be lower in the DS group (7.09±1.68 pmol/L) vs controls (7.92±1.39 pmol/L) (t=2.4; P=.05).

We observed a

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Down Syndrome and 3,3′,5′-Triiodothyronine

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Down Syndrome and 3,3′,5′-Triiodothyronine

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