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April 1990

Newborn Screening for Hemoglobinopathies in Colorado: The First 10 Years

Author Affiliations

From the Department of Pediatrics and the Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine (Drs Githens and Lane and Mss Houston and Cole) and the Mountain States Newborn Screening Laboratory, Colorado Department of Health (Dr McCurdy and Mr McKinna), Denver.

Am J Dis Child. 1990;144(4):466-470. doi:10.1001/archpedi.1990.02150280088018

• In Colorado, newborn screening for hemoglobinopathies by cellulose acetate and citrate agar electrophoresis of dried capillary blood spots was established in 1979. We reviewed the results of screening 528 711 infants through 1988. Forty-seven infants with sickle cell diseases and 27 infants with other hemoglobin diseases were identified. The initial screening failed to detect sickle cell anemia in 4 infants, but the hemoglobinopathy in 3 of these infants was diagnosed correctly by routine retesting of those with suspected sickle cell trait. A total of 47 infants with sickle cell diseases were followed through September 1989. There was no mortality among these infants. The screening test identified 3779 infants (1:140 births) with a suspected hemoglobin trait; confirmatory retesting was obtained in 53%. The results of our experience confirm the value of newborn screening for hemoglobinopathies but suggest that a more sensitive test would improve the program.

(AJDC. 1990;144:466-470)

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