Sir.—Osler1 described the association of blue sclerae and iron deficiency anemia in teenaged girls. That finding received apparent further support from Kalra et al2 in a study of adult inpatients. We sought to validate this association in infants and young children. Thirty-four patients, ages 4 months to 5 years, 25 of whom were black and nine white, were examined by a pediatric house officer and attending physician. Anemia was defined as a hemoglobin value less than 105 g/L in children less than 2 years of age and less than 115 g/L in those over 2 years of age. The diagnosis of iron deficiency was confirmed by a free erythrocyte protoporphyrin value greater than 350 g/L of whole blood. Five of the 34 study patients had blue sclerae and only two of these five were anemic. Thus three patients with blue sclerae had no laboratory evidence of
BARTON LL, FRIEDMAN AD. Blue Sclerae and Iron Deficiency. Am J Dis Child. 1990;144(11):1180–1181. doi:10.1001/archpedi.1990.02150350010006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: