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April 1991

Picture of the Month

Author Affiliations

Contributed from the Institute of Pediatric and Adolescent Endocrinology (Drs Laron and Klinger) and Department of Pediatric Roentgenology (Dr Grunebaum), Beilinson Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv (Israel) University.

Am J Dis Child. 1991;145(4):473-474. doi:10.1001/archpedi.1991.02160040135023

Denouement and Discussion 

Laron-Type Dwarfism 

Manifestations  Laron-type dwarfism is characterized by marked growth retardation, acromicria (small hands, feet, and chin), obesity, and micropenis. Craniofacial abnormalities include a protruding forehead, saddle nose, and an increased biparietal-bicondylar ratio, all caused by marked underdevelopment of the facial bones. Head circumference is decreased, skeletal maturation is markedly retarded, the bones are very thin, and there is an increased incidence of minor skeletal abnormalities such as slipped femoral epiphyses and Legg-Calve-Perthes disease. The obesity is generalized and there is underdevelopment of muscle mass. Genitalia and gonads are small, and

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