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December 1992

Acute Scrotal Involvement in Children With Familial Mediterranean Fever

Am J Dis Child. 1992;146(12):1419-1420. doi:10.1001/archpedi.1992.02160240029009

Sir.—Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology that is common among Sephardic Jews, Arabs, Armenians, and other ethnic groups of the Mediterranean basin.1,2 It is principally a pediatric disease with onset in the first decade of life in more than 50% of cases. It is characterized by recurrent, acute, self-limited episodes of fever and polyserositis including peritonitis, arthritis, pleuritis, and various skin lesions.3 In some of the patients, the course of the disease may be complicated by the development of generalized amyloidosis leading to renal failure, which can be fatal.4

Acute inflammation of the scrotum in children with FMF is not a well-recognized entity. It can be manifested alone or in conjunction with peritonitis (abdominal attack). In this report we describe eight children with FMF in whom acute scrotal inflammation developed sometime before or after the diagnosis of FMF was made.


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