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October 1993

Intrauterine Meconium Aspiration in an Extremely Premature Infant

Am J Dis Child. 1993;147(10):1035-1037. doi:10.1001/archpedi.1993.02160340021004

Sir.—Typically, the infant with meconium aspiration syndrome (MAS) is a term or postterm neonate with a birth weight exceeding 2500 g. In a series of 88 meconium-stained infants, Gregory et al1 found a mean birth weight of 2911 g and a mean gestation of 290 days or 10 days after the expected delivery date.1 After reviewing 125 cases of meconium-stained infants, Ting and Brady2 reported similar results.

In utero meconium passage occurs in only 3% of infants of gestational age younger than 36 weeks.3 In the past, meconium aspiration has been regarded entirely as a postnatal event. We report an unusual case of intrauterine meconium aspiration in a premature infant.

Patient Report.—A 610-g white male neonate was born to a 24-year-old gravida 2, para 0010 mother at 27 weeks' gestation by dates and examination. The pregnancy was complicated by maternal diethylstilbestrol exposure, hyperemesis, and