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October 1993

Neonatal Hemochromatosis Associated With Maternal Autoantibodies Against Ro/SS-A and La/SS-B Ribonucleoproteins

Am J Dis Child. 1993;147(10):1072-1075. doi:10.1001/archpedi.1993.02160340058014

• Liver disease in the fetus and neonate may be associated with maternal Sjögren's syndrome (neonatal lupus erythematosus). The infant of a mother with Sjögren's syndrome and high anti-Ro/SS-A and anti-La/SS-B antibody titers presented at 2½ weeks of age with overwhelming hepatic insufficiency and died at 6 weeks of age. Autopsy confirmed the antemortem diagnosis of neonatal hemochromatosis. We discuss the possibility of a relationship between these two conditions.

(AJDC. 1993;147:1072-1075)