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February 1995

Granulocyte Colony-Stimulating Factor for Neutropenia in Neonatal Sepsis

Author Affiliations

Section of Neonatology Department of Pediatrics The Ohio State University College of Medicine and Columbus Children's Hospital 700 Children's Dr Columbus, OH 43205

Arch Pediatr Adolesc Med. 1995;149(2):218-219. doi:10.1001/archpedi.1995.02170140100021

Murray et al1 recently reported on the use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) for neutropenia due to congenital neonatal sepsis in a preterm infant. We describe a premature infant in whom neutropenia due to Klebsiella sepsis developed at 8 days of age and who received rhG-CSF, resulting in the rapid resolution of neutropenia but with a different onset of action, magnitude, and duration of response.

Patient Report.  A 1446-g male infant was born at 32 weeks' gestation to a 28-year-old insulin-dependent primigravida. The patient's initial postnatal course was remarkable for mild respiratory distress, transient hypoglycemia, indirect hyperbilirubinemia, and a 7-day course of intravenous ampicillin sodium for presumed group B Streptococcus sepsis (a positive urine latex agglutination test and negative blood culture). At 8 days of age, necrotizing enterocolitis developed and his white blood cell and absolute neutrophil counts fell over 24 hours from 7.0 and 4.48× 10