Emre et al1 published their interesting results in the Archives on the association between Chlamydia pneumoniae infection and reactive airway disease, not previously documented in children. They used both cultural and serological methods for determining C pneumoniae infection. In our study from 1981 to 1982,2 chlamydial infection was indicated serologically in 14 (3%) of the 449 children with lower respiratory tract infection. The ages varied from 1 month to 8 years (1 to 11 months in three cases, 12 to 23 months in five cases, and older than 24 months in six cases). In all the patients, the chlamydial cause was assessed by using enzyme immunoassay for measurement of immunoglobulin class-specific antibodies to the lipopolysaccharide antigen common to all chlamydial species.3 Paired serum samples giving a threefold or greater rise were studied further by microimmunofluorescence, the same method used by Emre et al,1 specific for C
Korppi M, Leinonen M, Saikku P. Chlamydial Infection and Reactive Airway Disease. Arch Pediatr Adolesc Med. 1995;149(3):341–342. doi:10.1001/archpedi.1995.02170150121026
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