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April 1996

Congenital Lymphocytic Choriomeningitis Virus Infection

Author Affiliations

Department of Pediatrics Steele Memorial Children's Research Center University of Arizona Health Sciences Center 1501 N Campbell Ave Tucson, AZ 85724-5073
Atlanta, Ga
Greenwood, SC
Omaha, Neb

Arch Pediatr Adolesc Med. 1996;150(4):440. doi:10.1001/archpedi.1996.02170290106019

Lymphocytic choriomeningitis virus (LCMV), an arenavirus perpetuated by chronic infection of mice, has been the agent of sporadic and epidemic disease in Europe and the Americas. Postnatal acquisition of LCMV may be inapparent or associated with systemic or central nervous system manifestations. Congenital LCMV infection, first recorded in England more than 40 years ago,1 has received virtually no attention outside of Germany2 and Lithuania.3 We have recently documented congenital LCMV infection in four infants4,5 and aided in the diagnosis in two additional neonates. The infection in all infants was manifested by chorioretinitis, hydrocephalus, intracranial calcifications, and psychomotor retardation. Infectious agents excluded by means of culture or serologic examination were Toxoplasma gondii, cytomegalovirus, herpes simplex virus, rubella, Treponema pallidum, mumps virus, human immunodeficiency virus, and enteroviruses. A history of rodent exposure was obtained in three of the four infants whom we personally examined. The diagnosis was confirmed