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October 1997

HIV Infection in Children: A Guide to Practical Management

Author Affiliations

Department of Pediatrics All Children's Hospital St Petersburg, FL 33701

Arch Pediatr Adolesc Med. 1997;151(10):1069. doi:10.1001/archpedi.1997.02170470103032

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The full effect of the epidemic of human immunodeficiency virus (HIV) infection is increasingly becoming evident in pediatrics with HIV-affected and HIV-infected patients. This book provides an excellent description of the underlying pathophysiological features of the immunity of HIV infection, enabling the reader to understand the disease process and its effect on adults and children. Research remains to be done on HIV's effect on the developing immune system of the fetus and the neonate and on the decreasing risk of vertical transmission and its variations related to specific risk factors (breast-feeding, maternal CD4+ cell count, maternal viral load, and prematurity).

This text teaches the prognostic importance of HIV-associated illnesses (Pneumocystis carinii pneumonia and cytomegalovirus) and signs (hepatosplenomegaly, lymphadenopathy, and diarrhea) as they apply to the current classification system and World Health Organization case definition. Two distinct phases of HIV childhood infection are delineated (rapidly progressive and slowly progressive

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