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Research Letter
Aug 2012

Prevalence of Human Papillomavirus Infection in Young Women Receiving the First Quadrivalent Vaccine Dose

Author Affiliations

Author Affiliations: Divisions of Adolescent Medicine (Drs Widdice and Kahn) and Infectious Diseases (Dr Bernstein) and Center for Epidemiology and Biostatistics (Dr Ding), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Departments of Medicine (Dr Brown), Microbiology and Immunology (Dr Brown), and Pediatrics (Drs Shew and Fortenberry), Indiana University School of Medicine, Indianapolis; and Rollins School of Public Health, Emory University, Atlanta, Georgia (Ms Patel).

Arch Pediatr Adolesc Med. 2012;166(8):774-776. doi:10.1001/archpediatrics.2012.586

The objective of this study was to determine human papillomavirus (HPV) prevalence and identify factors associated with infection in sexually experienced and inexperienced females initiating HPV vaccination.


Participants were 13- to 21-year-old females receiving their first HPV vaccine dose, recruited from an adolescent primary care clinic between June 2008 and June 2010. These data are from the baseline visit of a longitudinal study that was approved by the hospital's institutional review board. Each participant completed a questionnaire assessing sociodemographic factors and behaviors. History of sexual contact was assessed using the following item: “Have you ever had sexual contact with a male or female (by sexual contact we mean genital, skin-to-skin contact only)?” Sexual experience was defined as a response of yes to the following item: “Have you ever had sex with a male or female (by sex we mean vaginal or anal sex)?” Cervicovaginal swabs were self- or clinician-collected and tested for HPV DNA.1,2 Logistic regression models were estimated to determine variables associated with HPV infection in sexually experienced and inexperienced females. The outcome measure was infection with 1 or more HPV types.