Type 2 Diabetes Mellitus in Children: Prenatal and Early Infancy Risk Factors Among Native Canadians | Pediatrics | JAMA Pediatrics | JAMA Network
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Article
July 2002

Type 2 Diabetes Mellitus in Children: Prenatal and Early Infancy Risk Factors Among Native Canadians

Author Affiliations

From the Departments of Community Health Sciences (Drs Young, Martens, and Taback and Mss Cheang and Flett) and Pediatrics and Child Health (Drs Taback, Sellers, and Dean), Faculty of Medicine, University of Manitoba and the Health Sciences Centre, Winnipeg; and the Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario (Dr Young).

Arch Pediatr Adolesc Med. 2002;156(7):651-655. doi:10.1001/archpedi.156.7.651
Abstract

Background  Type 2 diabetes mellitus is increasingly being observed among children and youth, including the Native population of Canada. Only one study has investigated prenatal and early infancy risk factors for the disease.

Methods  A case-control study was conducted; 46 patients younger than 18 years were recruited from the only clinical center for the treatment of diabetes serving the province of Manitoba, and 92 age- and sex-matched controls were recruited from a pediatric ambulatory clinic serving a large Native population in Winnipeg, Manitoba. Information on exposure to prenatal and early infancy risk factors was obtained through questionnaires administered by a Native nurse-interviewer.

Results  Multiple logistic regression modeling identified preexisting diabetes (odds ratio [OR], 14.4; 95% confidence interval [CI], 2.86-72.5), gestational diabetes (OR, 4.40; 95% CI, 1.38-14.1), and breastfeeding longer than 12 months (OR, 0.24; 95% CI, 0.13-0.99) as significant independent predictors of diabetic status. Other factors, such as low (<2500 g) and high (>4000 g) birth weight and maternal obesity, were also associated with diabetes in our population, but the elevated risks were not statistically significant.

Conclusion  Breastfeeding reduces the risk of type 2 diabetes among Native Canadian children and should be promoted as a potential intervention to control the disease.

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