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Assisted reproductive technology (ART) has extensively permitted thousands of childbirths per year for many infertile couples throughout the world.1 Although ART is generally considered safe, a growing body of evidence reveals the association of ART with increased risk for poorer perinatal outcomes and congenital malformations.2 Furthermore, preliminary studies have indicated the presence of cardiovascular remodeling in fetuses and infants conceived with ART potentially associated with fetal cardiovascular reprogramming.3,4 However, very little is known regarding whether cardiovascular changes occurring already in fetal life among pregnancies conceived with ART persist into childhood and retain an incremental risk of developing cardiac remodeling. On the basis of a prospective follow-up of a historic national register–based cohort study, we designed an observational study to investigate cardiac development of children conceived with ART compared with those conceived spontaneously at age 5 years.
Liu H, Zhang Y, Gu H, et al. Association Between Assisted Reproductive Technology and Cardiac Alteration at Age 5 Years. JAMA Pediatr. 2015;169(6):603–605. doi:10.1001/jamapediatrics.2015.0214
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