[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Research Letter
June 2015

Association Between Assisted Reproductive Technology and Cardiac Alteration at Age 5 Years

Author Affiliations
  • 1Department of Cardiac Surgery, Clinical Center of Heart and Great Vessels, Research Institute of Heart, Lung, and Blood Vessel Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • 2State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • 3Department of Pediatric Cardiothoracic Surgery, Jiangsu Women and Children Health Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • 4Ministry of Education Key Laboratory of Clinical Diagnostic Medicine, Institute of Laboratory Medicine, Chongqing Medical University, Chongqing, China
  • 5Echocardiography Group, Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cardiovascular Disease of Translational Medicine of Jiangsu Province, Nanjing, China
  • 6Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
JAMA Pediatr. 2015;169(6):603-605. doi:10.1001/jamapediatrics.2015.0214

Assisted reproductive technology (ART) has extensively permitted thousands of childbirths per year for many infertile couples throughout the world.1 Although ART is generally considered safe, a growing body of evidence reveals the association of ART with increased risk for poorer perinatal outcomes and congenital malformations.2 Furthermore, preliminary studies have indicated the presence of cardiovascular remodeling in fetuses and infants conceived with ART potentially associated with fetal cardiovascular reprogramming.3,4 However, very little is known regarding whether cardiovascular changes occurring already in fetal life among pregnancies conceived with ART persist into childhood and retain an incremental risk of developing cardiac remodeling. On the basis of a prospective follow-up of a historic national register–based cohort study, we designed an observational study to investigate cardiac development of children conceived with ART compared with those conceived spontaneously at age 5 years.