Link Between Increased Prevalence of Autism Spectrum Disorder Syndromes and Oxidative Stress, DNA Methylation, and Imprinting: The Impact of the Environment | Autism Spectrum Disorders | JAMA Pediatrics | JAMA Network
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Research Letter
November 2015

Link Between Increased Prevalence of Autism Spectrum Disorder Syndromes and Oxidative Stress, DNA Methylation, and Imprinting: The Impact of the Environment

Author Affiliations
  • 1London Fertility Associates, London, England
  • 2Bourn Hall Clinic, Cambridge, England
  • 3Centre for Assisted Fertilization, Naples, Italy
JAMA Pediatr. 2015;169(11):1066-1067. doi:10.1001/jamapediatrics.2015.2125

Autism is a complex neurodevelopment disorder, with a male to female prevalence of 4.3:1. The number of children diagnosed with autism or related disorders has increased at an alarming rate: the Centers for Disease Control and Prevention estimates that 1 in 68 children in the United States (or 14.7 per 1000 eight-year-olds) was identified with autism spectrum disorder during 2014. The figure reaches 1 in 45 children in the state of Alabama, and this represents an estimated 30% increase over previous estimates reported in 2012. The prevalence of these disorders has more than doubled since 2000. Here we discuss the biochemical link between the process of DNA methylation in gametes and autism.

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