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Zika virus continues to infect pregnant women across a large portion of the Americas. Ellington and coauthors develop models to predict the number of pregnant women infected with Zika virus in Puerto Rico and the resultant number of infants with congenital microcephaly. Using available data, they estimated that 5900 to 10 300 pregnant women might be infected during the initial Zika virus outbreak in Puerto Rico, resulting in 100 to 270 cases of congenital microcephaly. The study underscores the urgent need for both public health control of the outbreak and research to develop a vaccine.
Prior research suggests that acetaminophen use in pregnancy is associated with abnormal fetal development. Stergiakouli and coauthors seek to determine whether this could be due to unmeasured confounding, using data on 7796 mothers in the Avon Longitudinal Study of Parents and Children. Children exposed to prenatal use of acetaminophen were at higher risk for multiple behavioral difficulties, not explained by mother’s postnatal use or partner’s use of acetaminophen. Given the widespread use of this drug, this has important implications for public health advice.
Highlights. JAMA Pediatr. 2016;170(10):919. doi:10.1001/jamapediatrics.2015.2557
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