Errors in Results and Figure | JAMA Pediatrics | JAMA Network
[Skip to Navigation]
Sign In
Views 410
Citations 0
October 14, 2019

Errors in Results and Figure

JAMA Pediatr. 2019;173(12):1216. doi:10.1001/jamapediatrics.2019.4189

In the Research Letter titled “Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days,”1 there were errors in the Results and Figure. During an analysis for a follow-up study, the authors identified a transcription error for the weight of one of the included infants in the data set, which slightly changed the study results. These changes do not affect the final outcome but do require the graphs in the Figure to be adjusted and the following changes to be made to the Results: “The θWT,CL was fixed at 0.75 because the model estimate was unstable.” “The 48-hour trough concentrations that provided a 90% probability of target attainment were greater than 15 to 20 mg/L for the 6-hour dosage interval and greater than 8 to 15 mg/L for the 12-hour dosage interval. Trough concentrations of approximately 30 mg/L were required to achieve an AUC24 greater than 800 mg.h/L (for an MIC of 2) for a 6-hour dosage interval and would not be achievable without increasing the risk of drug-related toxic effects.” This article was corrected online. This article was previously corrected in August 2019 for errors in vancomycin trough concentration values in the Results.

Gwee  A, Cranswick  N, McMullan  B,  et al.  Defining target vancomycin trough concentrations for treating Staphylococcus aureus infection in infants aged 0 to 90 days  [published correction appears in JAMA Pediatr. 2019;173(8):801].  JAMA Pediatr. 2019;173(8):791-793. doi:10.1001/jamapediatrics.2019.1488PubMedGoogle ScholarCrossref