Customize your JAMA Network experience by selecting one or more topics from the list below.
Death and disease in adult patients from the COVID-19 pandemic continue unabated across the world well into 2021,1 and why children have escaped severe disease from this virus2 remains one of the most intriguing gaps in our understanding of the immune response to this virus. Of equal imperative, what insights can be gained via a deeper understanding as to why some children do become critically ill from COVID-19 and the more recently described multisystem inflammatory syndrome in children (MIS-C)? Unlocking the key immunologic mechanisms driving these outcomes will likely initially emerge from meticulous epidemiologic studies that describe the few children who do get very ill from this disease.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Blumenthal JA, Burns JP. Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When. JAMA Pediatr. Published online April 06, 2021. doi:10.1001/jamapediatrics.2021.0638
Create a personal account or sign in to: