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Special Feature
November 2000

Picture of the Month

Author Affiliations
 

WALTER W.TUNNESSENMD

Arch Pediatr Adolesc Med. 2000;154(11):1161. doi:

Figure 1. Saliva and gastric fluid have dissolved the outer pink coating, revealing the bilayer brown and yellow appearance of the Gastrointestinal Therapeutic System.

Figure 2. Procardia XL 30-mg tablet (Pfizer Inc, New York, NY).

Figure 3. The tablet's pink coating dissolves readily under tap water.

Figure 4. The nifedipine Gastrointestinal Therapeutic System.1

The nifedipine GITS is the key functional element in Pfizer's extended-release Procardia formulation.1 This proprietary technology was designed to provide zero-order delivery of the drug over a 24-hour period. The convenient dosing regimen is believed to have improved compliance with calcium channel blocker therapy in hypertensive patients.2 Many pediatricians may be unfamiliar with this product, encountering it only in the setting of a suspected poisoning. A review of the product's formulation design is necessary to understand the appearance of tablets after ingestion.

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