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Special Feature
December 7, 2009

Picture of the Month—Diagnosis

Arch Pediatr Adolesc Med. 2009;163(12):1158. doi:10.1001/archpediatrics.2009.221-b

Denouement and Discussion: Mycoplasma pneumoniaePneumonia With Associated Urticaria Multiforme Rash

Figure 1and Figure 2depict the classic lesions of urticaria multiforme. Urticaria multiforme, a form of acute annular urticaria, is an allergic hypersensitivity reaction mediated by histamine that may be IgE dependent or independent.1The lesions are annular and polycyclic. They blanch with pressure and may display a central purplish or dusky hue. Because of similarities in the appearance of the rash, urticaria multiforme is often misdiagnosed as erythema multiforme and, less commonly, as serum sickness.

Figure 1. 


Figure 2. 


The term urticaria multiformewas proposed1to describe this form of annular urticaria2,3to emphasize the clinical manifestations that differentiate it from erythema multiforme. The lesions of urticaria multiforme may have dusky skin changes in central areas of polycyclic lesions, but these changes disappear without leaving the “bruising” that is commonly seen with erythema multiforme. True necrosis or blistering of the skin is never seen with urticaria multiforme and there is no associated mucous membrane involvement. Also, the lesions of urticaria multiforme are evanescent, with individual lesions lasting less than 24 hours, which further distinguishes it from the fixed lesions of erythema multiforme. The presence of dermatographism can also help to support the diagnosis of urticaria multiforme. Because urticaria multiforme is commonly associated with facial or acral edema it may also be confused with serum sickness–like reactions.1,3,4Although swelling of the feet may make walking painful and difficult, true arthralgias or arthritis are not associated with urticaria multiforme. Importantly, the angioedema present in urticaria multiforme has not been associated with laryngoedema and has not been reported to be associated with food allergy.1,5Suggested treatment for urticaria multiforme involves complete histamine receptor blockage. Long-duration H1blockers (such as cetirizine hydrochloride) should be given in association with H2blockers (such as ranitidine) with breakthrough relief as needed by diphenhydramine or hydroxyzine hydrochloride. Most patients have symptom relief with this combination within a few days to 2 weeks.1Steroids should be reserved for patients who remain severely symptomatic despite antihistamine therapy. Treatment is largely symptomatic, as episodes of urticaria multiforme are self-resolving within 8 to 10 days.

Urticaria among children is more commonly associated with infectious rather than allergic etiologies.3,4As a subset of urticarial eruptions, urticaria multiforme is also commonly associated with infection. In 1 retrospective study, 17% of patients with urticaria multiforme had laboratory-confirmed infection, including 1 patient with Mycoplasma pneumoniaepneumonia.1

The patient presented herein had clinical and radiographic findings consistent with pneumonia. His chest radiograph revealed a patchy opacity at the left lung base (Figure 3). Nasopharyngeal aspirate testing by polymerase chain reaction (PCR) confirmed the diagnosis of M pneumoniae. M pneumoniaehas also been associated with extrapulmonary complications, including myocarditis, pericarditis, encephalitis, aseptic meningitis, transverse myelitis, Guillain-Barre syndrome, hemolytic anemia, myalgias, and rash.6M pneumoniaeis the main cause of erythematous rash in the setting of pneumonia and is associated with both erythema multiforme and Stevens-Johnson syndrome.6-8However, M pneumoniaeis also associated with urticaria, as seen in the patient presented herein.1,6

Testing for M pneumoniaehas recently shifted to PCR techniques; however, some authors suggest that serologic studies should be performed in conjunction with PCR testing to increase the overall sensitivity of disease detection.9,10Treatment for M pneumoniaeincludes tetracyclines, macrolides, or fluoroquinolones.8

The patient presented herein was treated with cetirizine and ranitidine with additional diphenhydramine as needed for his urticaria as well as azithromycin for M pneumoniaepneumonia. The symptoms began to resolve at the time of discharge 2 days later.

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Correspondence:Sage R. Myers, MD, Children's Hospital of Philadelphia, Emergency Medicine Offices, A-level, Main Bldg, AS01, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 (myerss@email.chop.edu).

Accepted for Publication:July 31, 2009.

Author Contributions:Study concept and design: Myers and Lavelle. Acquisition of data: Myers. Analysis and interpretation of data: Myers. Drafting of the manuscript: Myers. Critical revision of the manuscript for important intellectual content: Myers and Lavelle. Administrative, technical, and material support: Myers. Study supervision: Lavelle.

Financial Disclosure:None reported.

Shah  KNHonig  PJYan  AC Urticaria multiforme: a case series and review of acute annular urticarial hypersensitivity syndromes in children.  Pediatrics 2007;119 (5) e1177- e1183PubMedGoogle ScholarCrossref
Weston  JAWeston  WL The overdiagnosis of erythema multiforme.  Pediatrics 1992;89 (4, pt 2) 802PubMedGoogle Scholar
Mortureux  PLéauté-Labrèze  CLegrain-Lifermann  VLamireau  TSarlangue  JTaïeb  A Acute urticaria in infancy and early childhood.  Arch Dermatol 1998;134 (3) 319- 323PubMedGoogle ScholarCrossref
Sackesen  CSekerel  BEOrhan  FKocabas  NTuncer  AAdalioglu  G The etiology of different forms of urticaria in childhood.  Pediatr Dermatol 2004;21 (2) 102- 108PubMedGoogle ScholarCrossref
Burks  W Skin manifestations of food allergy.  Pediatrics 2003;111 (6, pt 3) 1617- 1624PubMedGoogle Scholar
Vervloet  LAMarguet  CCamargos  PA Infection by Mycoplasma pneumoniaeand its importance as an etiological agent in childhood community-acquired pneumonias.  Braz J Infect Dis 2007;11 (5) 507- 514PubMedGoogle ScholarCrossref
Lam  NSYang  YHWang  LCLin  YTChiang  BL Clinical characteristics of childhood erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Taiwanese children.  J Microbiol Immunol Infect 2004;37 (6) 366- 370PubMedGoogle Scholar
Schalock  PCDinulos  JGPace  NSchwarzenberger  KWenger  JK Erythema multiforme due to Mycoplasma pneumoniaeinfection in two children.  Pediatr Dermatol 2006;23 (6) 546- 555PubMedGoogle ScholarCrossref
Martínez  MARuiz  MZunino  ELuchsinger  VAvendano  L Detection of mycoplasma pneumoniae in adult community-acquired pneumonia by PCR and serology.  J Med Microbiol 2008;57 (pt 12) 1491- 1495PubMedGoogle ScholarCrossref
Kashyap  BKumar  SSethi  GRDas  BCSaigal  S Comparison of PCR, culture and serologic tests for the diagnosis of Mycoplasma pneumoniaein community-acquired lower respiratory tract infections in children.  Indian J Med Res 2008;128 (2) 134- 139PubMedGoogle Scholar