Original studies and observations concerned with the diagnosis and treatment of diseases commonly or exclusively seen in children are the focus of the May issue of the Archives of Dermatology. Common therapeutic concerns of children and adolescents are immunotherapy of warts, isotretinoin to treat acne, and the use of general anesthesia for pediatric dermatologic procedures. More unusual treatment is presented for brown recluse spider bites and infantile digital fibromatosis. Pediatric diagnostic reports include aplasia cutis congenita and the risk of sagittal sinus thrombosis, restrictive dermopathy associated with transposition of the great arteries, and aquagenic wrinkling of the palms in patients with cystic fibrosis.