Archives of Pediatrics & Adolescent Medicine will publish a special theme issue in April 2007 on autism spectrum disorders including autism to foster a better understanding of the environmental and genetic risk (and protective) factors for autism; efficient and sensitive methods to screen for autism, especially in the primary care physician's office; confirmatory tools to accurately diagnosis autism and autism spectrum disorders; and information on the natural history of autism. We are especially interested in rigorously conducted studies on interventions for children with autism, as well as for their families. We will be happy to consider articles that consider policy implications of diagnosis and treatment of children with autism from the point of view of their families, communities, schools, and society as a whole. Papers submitted by September 1, 2006, will have the best chance for inclusion in this issue. Please consult our Web site at www.archpediatrics.com for submission information.