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February 1969

Diabetes Insipidus Complicating Acute Lymphocytic Leukemia

Author Affiliations

From the Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland.

Am J Dis Child. 1969;117(2):228-230. doi:10.1001/archpedi.1969.02100030230020

DIABETES insipidus complicating acute leukemia has been reported but rarely. In a comprehensive review Rosensweig and Kendall1 found 12 such cases, only one of which was in a child. The patient was recorded to have had acute granulocytic leukemia.2 Of the remaining 11 adult patients, only one had acute lymphocytic leukemia.3 This report presents the first well-documented case of diabetes insipidus complicating acute lymphocytic leukemia in a child.

Report of a Case  A 10-year-old Negro girl with acute lymphocytic leukemia was admitted to the Children's Clinical Research Center of University Hospitals of Cleveland in August 1967 following one month of polyuria and polydipsia.She had first presented ten months earlier with fever, dyspnea, and chest pain at which time a left pleural effusion was noted radiographically. Thoracentesis followed by biopsy and examination of scalene and anterior mediastinal lymph nodes established a diagnosis of lymphocytic lymphoma. Other abnormal

Rosensweig, A., and Kendall, J.:  Diabetes Insipidus as a Complication of Acute Leukemia ,  Arch Intern Med 117:397-400 ( (March) ) 1966.Crossref
Joseph, M., and Levin, S.:  Leukemia and Diabetes Insipidus ,  Brit Med J 1:1328-1331 ( (June 9) ) 1956.Crossref
Flynn. J.:  Lymphatic Leukemia With Diabetes Insipidus and Uremia ,  J Urol 58:106-111 ( (Aug) ) 1947.
Lewis, A., and Chalmers, T.:  A Nicotine Test for the Investigation of Diabetes Insipidus ,  Clin Sci 10:137-144 ( (Feb) ) 1951.
Cates, J., and Garrod, O.:  Effect of Nicotine on Urinary Flow in Diabetes Insipidus ,  Clin Sci 10:145-160 ( (Feb) ) 1951.
 Neurological Complications of Lymphoma and Leukemia , Publication No. 357, American Lecture Series, Springfield, Ill: Charles C Thomas, Publisher, 1959.