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Letters to the Editor
January 2002

Eicosapentaenoic Acid in Treatment-Resistant Depression

Arch Gen Psychiatry. 2002;59(1):91-92. doi:

Almost a third of patients with depression fail to respond to existing treatments, and new treatments are required. Epidemiological evidence about fish intake1 and blood levels of the relevant fatty acids2-4 suggests that increased intakes of ω3 fatty acids such as eicosapentaenoic acid (EPA) may be helpful. A mixture of EPA and docosahexaenoic acid has been reported to improve depression and the course of illness in bipolar disorder,5 but to date, there are no reports of treatment of unipolar depression using this approach.

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