Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
Mirtazapine has been reported to target symptoms of anxiety (agitation,
somatization, psychic anxiety, panic attacks) that often occur in depressed
Enhancement of both noradrenergic and serotonergic transmission through α
autoreceptor and α-heteroreceptor antagonism, respectively, coupled
with the blockade of 5-HT2 and 5-HT3 receptors, has
been considered the main mechanism of this apparent pharmacological efficacy
for anxiety symptoms.3,4
Additionally, H1 receptor antagonism facilitates an initial soporific
Carli V, Sarchiapone M, Camardese G, Romano L, DeRisio S. Mirtazapine in the Treatment of Panic Disorder. Arch Gen Psychiatry. 2002;59(7):661–662. doi:10.1001/archpsyc.59.7.661
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: