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Letters to the Editor
June 2012

BRIDGE Study Warrants Critique—Reply

Author Affiliations

Author Affiliations: Division of Psychiatry, Centre for Mental Health, Imperial College, London, England (Dr Young); Division of Psychiatric Research, Zürich University Psychiatric Hospital, Zürich, Switzerland (Drs Angst and Gamma); Division of Psychiatry, Hôpital de Sainte-Marguerite, Marseille, France (Dr Azorin); Hospital Clinic, University of Barcelona, Institut d’Investigació Biomèdica August Pi i Sunyer–Centro de Investigación Biomèdica En Red de Salud Mental, Barcelona, Spain (Dr Vieta); and Departments of Psychiatry, University of Pisa, Pisa, Italy (Dr Perugi), and University of Texas Health Science Center, San Antonio (Dr Bowden).

Arch Gen Psychiatry. 2012;69(6):644-645. doi:10.1001/archgenpsychiatry.2012.120

In reply

We are pleased to respond to the points raised by Allen et al, some of which take material out of context and quote news media articles beyond our control. For example, the letter states that “The message is that almost half the patients with a major depressive episode have undiagnosed bipolar disorder and are ‘not receiving necessary mood stabilizer treatment.’” Our actual statements are:

Based on these studies and the major differences in treatment guidelines for MDD [major depressive disorder] and bipolar disorder, we recommend that, among patients with MDEs [major depressive episodes], the presence of bipolar features, including all those with significant predictive value reported in this study, should be investigated carefully before a decision is made to prescribe antidepressants. If patients exhibit bipolar symptoms that impair everyday functioning, treatment with a mood stabilizer or an atypical antipsychotic may be useful.1(p797)

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