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June 2013

The Potential Value of a Negative Finding: An Illustrative Example

Author Affiliations

Author Affiliations: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

JAMA Psychiatry. 2013;70(6):571-572. doi:10.1001/jamapsychiatry.2013.1116

Clinical trials with positive findings are more likely to be submitted and published than those with negative findings,1 but negative findings can provide invaluable information, particularly when based on sound methodology. The study by Somoza and colleagues2 in this issue provides a powerful illustration of the potential value of a negative finding.