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September 2013

Antipsychotic Medication During the Critical Period Following Remission From First-Episode Psychosis: Less Is More

Author Affiliations
  • 1Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
JAMA Psychiatry. 2013;70(9):898-900. doi:10.1001/jamapsychiatry.2013.264

If you come to a fork in the road, take it.

Yogi Berra

The person recovering from a first episode of psychosis (FEP), the family, and the treating clinical team have until now faced a real dilemma. Having reached the base camp of remission of psychotic symptoms, how long should antipsychotic medication be continued? Most guidelines propose a trial of dose reduction and discontinuation, all being well, after 12 months of treatment with careful monitoring subsequently. However, it is only recently that studies have been carried out to derive evidence regarding this decision.

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