[Skip to Navigation]
Comment & Response
December 2013

Antidepressant Medication and Spontaneous Abortion: “No Significant Association”? Clinically Significant Association!

Author Affiliations
  • 1The Joanna Briggs Institute, School of Translational Health Science, Faculty of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia
  • 2Department of Psychological Medicine, Women’s and Children’s Hospital, North Adelaide, South Australia, Australia
JAMA Psychiatry. 2013;70(12):1373-1374. doi:10.1001/jamapsychiatry.2013.2274

To the Editor Ross et al reported “no significant association between antidepressant medication exposure and spontaneous abortion (odds ratio [OR], 1.47; 95% CI, 0.99 to 2.17; P = .055)” (italics, our emphasis).1(p436) Confidence intervals provide inferential evidence about the range of plausible values for the population parameter of interest.2,3 A simple examination of the values covered by the reported 95% CI from 0.99 to 2.17 suffices to show that an association between the exposure to antidepressant medication and spontaneous abortion is likely and that results are nonnegligible from a clinical perspective. Results are not statistically significant but the differences are of clinical interest.

Add or change institution