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April 2014

Neurocognitive Growth Charts and Psychosis: Is the Relationship Predictive?

Author Affiliations
  • 1Department of Psychology, Yale University, New Haven, Connecticut
  • 2Department of Psychiatry, Yale University, New Haven, Connecticut
JAMA Psychiatry. 2014;71(4):361-362. doi:10.1001/jamapsychiatry.2013.4640

In this issue of JAMA Psychiatry, Gur et al1 evaluated differences in age-related neurocognitive test performance and psychosis symptoms in the context of a large population-based cohort. The rationale for this study grew out of observations that psychotic symptoms are relatively common in the general population2 and that individuals who have had a recent emergence of psychoticlike symptoms, but of subpsychotic intensity, are at increased risk for progressing to full psychosis within a few years of ascertainment.3,4 Given that such prodromal cases show neurocognitive deficits similar to those observed in first-episode schizophrenia,4,5 the Gur et al1 study sought to extend evidence of this link to participants with psychotic symptoms as ascertained through primary care, independently of seeking treatment for psychiatric indications.

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