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Letters to the Editor
January 1998

Nonresponse of Adrenocorticotropic Hormone in First-Ever Lactate-Induced Panic Attacks in Healthy Volunteers—Reply

Author Affiliations
  • 1Department of Therapeutics, New York State Psychiatric Institute, 722 W 168th St, Unit 22, New York, NY 10032
Arch Gen Psychiatry. 1998;55(1):86. doi:10.1001/archpsyc.55.1.86

In reply

Kellner and Wiedemann studied adrenocorticotropic hormone secretion in 2 healthy volunteers who experienced a first-ever panic attack during lactate infusion. No adrenocorticotropic hormone response was found despite the novelty of this experience.

In our extensive experience with 52 volunteers given lactate infusions, only 1 had a panic attack. In this subject, like in our patients with panic disorder, there was a slight decrement in baseline cortisol measures during the panic period despite the usual signs of vegetative arousal.