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Letters to the Editor
January 1998

Mania Induced by Withdrawal of Treatment With Interferon Alfa

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Gen Psychiatry. 1998;55(1):88-89. doi:

Patients treated with interferon alfa are frequently subject to mood disorders.1 This report describes 2 cases of mania subsequent to withdrawal of treatment with interferon alfa observed during a prospective study of a cohort of 44 patients affected by chronic hepatitis B receiving long-term treatment. Both subjects had normal findings on personal and family histories for psychiatric disorders.