The letter by Ross et al is another chapter in an oscillation between the preeminence of "qualitative" and "quantitative" ratings of smooth pursuit eye movements in schizophrenia. This area of inquiry is arguably the most vexing and polarized in the study of schizophrenia-linked cognitive and information processing dysfunction.1,2 The stakes are now increased because of evidence that informed neuro-ophthalmological measures in schizophrenia may be excellent "intermediate" phenotypic markers in genetic linkage studies.3 Thus, the robust identification and utilization of neuro-ophthalmological and other physiological markers in schizophrenia research has become more important.4
Braff DL. Specific Measures Account for Most of the Variance in Qualitative Ratings of Smooth Pursuit Eye Movements in Schizophrenia. Arch Gen Psychiatry. 1998;55(2):185–186. doi:
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