Several laboratories using functional neuroimaging techniques have recently reported that patients with posttraumatic stress disorder (PTSD) have increased blood flow or metabolism in right limbic, paralimbic, and frontal cortical structures when recalling the traumatic event associated with their symptoms.1-4 This observation is consistent with several studies implicating preferential right hemispheric involvement in the experience of unpleasant emotion.5-10 Taken together, these findings suggest that right limbic and paralimbic structures are intimately involved with the emotional symptoms associated with traumatic memories,11 and could potentially be the target of neurobiological treatment strategies.
McCann UD, Kimbrell TA, Morgan CM, et al. Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder. Arch Gen Psychiatry. 1998;55(3):276–279. doi:
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: