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Letters to the Editor
August 1998

Randomized Controlled Trials in Archives of General Psychiatry (1959-1995): A Prevalence Study

Arch Gen Psychiatry. 1998;55(8):754-755. doi:

A single randomized controlled trial (RCT) is often not powerful enough to guide practice. Systematic reviews, compiled from every relevant trial, frequently give more confident directions for practice. The Cochrane Collaboration1 produces, electronically maintains, and disseminates systematic reviews of the effects of health care interventions. However, because electronic databases are an inadequate source for trials, hand-searching of relevant literature is often undertaken.2

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