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Letters to the Editor
September 1998

Distinguishing Apathy Syndromes From Vascular Depression

Arch Gen Psychiatry. 1998;55(9):844-845. doi:10.1001/archpsyc.55.9.844

In their article proposing a "‘Vascular Depression' Hypothesis," Alexopoulos et al1 distinguish a very significant group of patients with features of depression, related to underlying vascular disease and neurological lesions. Though they acknowledge that their concept is broad and encompasses many pathogenetic processes, I would contend that many of the patients they consider as having vascular depression may be more appropriately classified as having an apathy syndrome instead.2

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