In their article proposing a "‘Vascular Depression' Hypothesis," Alexopoulos et al1 distinguish a very significant group of patients with features of depression, related to underlying vascular disease and neurological lesions. Though they acknowledge that their concept is broad and encompasses many pathogenetic processes, I would contend that many of the patients they consider as having vascular depression may be more appropriately classified as having an apathy syndrome instead.2
Fones CSL. Distinguishing Apathy Syndromes From Vascular Depression. Arch Gen Psychiatry. 1998;55(9):844–845. doi:10.1001/archpsyc.55.9.844
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