In their excellent review on the relationship of depression to cardiovascular disease, Musselman et al1 conclude that major depression and its associated symptoms constitute a major risk factor for both the development of cardiovascular disease and death after an index myocardial infarction. In their discussion on potential pathophysiological mechanisms underlying this relationship, however, they do not mention one factor which we believe is crucial to this topic—a possible deficiency of omega-3 fatty acids.
Severus WE, Ahrens B, Stoll AL. Omega-3 Fatty Acids—The Missing Link? Arch Gen Psychiatry. 1999;56(4):380–381. doi:10.1001/archpsyc.56.4.380
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.