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Letters to the Editor
April 1999

Omega-3 Fatty Acids—The Missing Link?

Arch Gen Psychiatry. 1999;56(4):380-381. doi:10.1001/archpsyc.56.4.380

In their excellent review on the relationship of depression to cardiovascular disease, Musselman et al1 conclude that major depression and its associated symptoms constitute a major risk factor for both the development of cardiovascular disease and death after an index myocardial infarction. In their discussion on potential pathophysiological mechanisms underlying this relationship, however, they do not mention one factor which we believe is crucial to this topic—a possible deficiency of omega-3 fatty acids.

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