IN THIS issue of the ARCHIVES, Stoll and colleagues1 report innovative preliminary data on the putative mood-stabilizing properties of a fish oil containing ω3 fatty acids in the treatment of bipolar disorder (types I and II).2 Acting on the assumption that overactive cell-signaling pathways may be involved in the pathophysiological characteristics of bipolar disorder3,4 and the finding that ω3 fatty acids are associated with a general dampening of signal transduction pathways associated with phosphatidylinositol, arachidonic acid, and other systems,5 Stoll et al performed a controlled study to explore the mood-stabilizing effects of high-dose ω3 fatty acids.