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Letters to the Editor
October 1999

Clozapine Plus Lamotrigine in Treatment-Resistant Schizophrenia

Arch Gen Psychiatry. 1999;56(10):950. doi:10.1001/archpsyc.56.10.950

Clozapine is the only antipsychotic agent with proven efficacy in treatment-resistant schizophrenia1; however, a substantial minority of patients fail to respond or have only a partial response to clozapine, leading clinicians to search for potential augmentation strategies to improve outcomes. To date, these augmentation strategies with clozapine have generally been disappointing.

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