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Letters to the Editor
February 2002

Olanzapine in Acute Bipolar Mania

Arch Gen Psychiatry. 2002;59(2):186. doi:

In reply

Thank you for the opportunity to respond to the "Letter to the Editor" that Dr Jagadheesan has written. Dr Jagadheesan correctly identifies a clear protocol violation associated with enrollment of a patient who did not meet the minimum Y-MRS requirement. Please note that in our analysis, however, adherence to the intent-to-treat principle motivates inclusion of this patient as randomized even though inclusion criteria for manic symptoms severity were not followed in this one instance.

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