Dr Davies states that Klein1 incorrectly
assumes that D-lactate is not metabolized by humans; thus, that our demonstration
of panic generation in panic patients by D-lactate infusion2
does not rule out lactate metabolism as a possible panicogenic process. He
cites articles anteceding ours to indicate our ignorance. However, the literature
of that time was still controversial since humans lack D-lactate dehydrogenase.
It was not until 1993 that Yasuda et al3
attributed D-lactate metabolism in humans to a specific enzyme.
Klein DF. D-Lactate and the False Suffocation Alarm. Arch Gen Psychiatry. 2002;59(3):287–288. doi:
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: